6533b851fe1ef96bd12a9897
RESEARCH PRODUCT
Photoredox-Catalyzed Four-Component Reaction for the Synthesis of Complex Secondary Amines.
Matthias KrumbJonas KühlbornJonas BusoldAlexander O. Terent'evBenjamin LippTill OpatzLisa Marie KammerBenjamin SpitzbarthOlga M. Mulinasubject
chemistry.chemical_classificationFour component010405 organic chemistryOrganic ChemistryFinal product010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistry0104 chemical sciencesStyreneCatalysischemistry.chemical_compoundchemistrySingle bondMoleculeAmine gas treatingPhysical and Theoretical ChemistryCounteriondescription
The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing substituted γ-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Besides one molecule of water and the sodium counterion of the sulfinate, all atoms of the starting materials are transferred to the final product, rendering this process highly atom-efficient. The operationally simple protocol allows for the simultaneous formation of three new single bonds (C-S, C-N, and C-C) and therefore grants rapid access to structurally diverse products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-03-11 | Organic letters |