6533b851fe1ef96bd12a98a5

RESEARCH PRODUCT

Eosinophil-selective mediators in human strongyloidiasis

Amparo MirR. IgualS. RullRafael BorrásD. BenahmedM. J. MorenoJosé-enrique O'connor

subject

AdultChemokine CCL11MaleEotaxinAdolescentImmunologyAntibodies HelminthImmunoglobulin EStrongyloides stercoralisEosinophil migrationmedicineAnimalsHumansInterleukin 5AgedEosinophil cationic proteinbiologyImmunoglobulin EMiddle Agedrespiratory systemEosinophilmedicine.diseasebiology.organism_classificationEosinophilsChemotaxis LeukocyteStrongyloidiasismedicine.anatomical_structureChemokines CCImmunologyStrongyloidiasisbiology.proteinFemaleParasitologyInterleukin-5Strongyloides stercoralis

description

SUMMARY Strongyloides stercoralis infection is characterized by the production of IgE and eosinophils in peripheral blood. Experimental studies have demonstrated that eosinophils play an important role in protection against Strongyloides stercoralis, but the mechanisms regulating eosinophils are not known. In this study we have focused on analysing the molecules that selectively regulate eosinophil migration, namely eotaxin and interleukin-5 (IL-5), using an enzyme-linked immunosorbent assay in patients with strongyloidiasis. Serum expression of eotaxin and IL-5 were significantly increased in patients compared with the control group. This rise suggests that selective mediators of the eosinophil can have a role in immunity against S. stercoralis in human infection.

yearjournalcountryeditionlanguage
2006-08-02Parasite Immunology
https://doi.org/10.1111/j.1365-3024.2006.00826.x