6533b851fe1ef96bd12a991c
RESEARCH PRODUCT
Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases.
Anna MaciagCarmine VecchioneMaurizio ForteFrancesco Antonio SalzanoAntonio D'amatoValentina TrimarcoAnnibale Alessandro PucaMichelangelo BartoloAlbino Carrizzosubject
Antioxidantmedicine.medical_treatmentBiological AvailabilityPharmacologyResveratrolBiologyToxicologymedicine.disease_causeAntioxidantsNitric oxidechemistry.chemical_compoundMetabolic DiseasesDiabetes mellitusStilbenesOxidative stress antioxidant brain cardiovascular diabetes nitric oxideDiabetes MellitusmedicineHumansClinical Trials as Topicfood and beveragesGeneral Medicinemedicine.diseaseBioavailabilityCerebrovascular DisordersOxidative StresschemistryCardiovascular DiseasesResveratrolToxicityOxidation-ReductionOxidative stressIntracellularFood Sciencedescription
Resveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |