6533b851fe1ef96bd12a9ac7

RESEARCH PRODUCT

Drug delivery from the oral cavity: focus on a novel mechatronic delivery device

Tomasz CiachLibero Italo GiannolaThomas Dr. VeltenAxel SchumacherOliver Dr. ScholzGiuseppina CampisiAndy Wolff

subject

Drugmedicine.medical_specialtymedia_common.quotation_subjectDentistryAdministration OralOral cavityDrug Delivery SystemsPharmaceutical technologyDrug DiscoverymedicineHumansIntensive care medicinemedia_commonPharmacologyDrug Implantsbusiness.industryMouth MucosaAdministration BuccalBuccal administrationEquipment DesignDental drug delivery Intra-oral drug delivery Dental prosthetic drug delivery Buccal delivery Controlled drug delivery MEMSDrug Therapy Computer-Assistedstomatognathic diseasesDrug deliveryDelivery systembusinessRetention time

description

Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery.

yearjournalcountryeditionlanguage
2007-06-29
10.1016/j.drudis.2007.10.018http://hdl.handle.net/10447/39354