Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors

6533b851fe1ef96bd12aa233

RESEARCH PRODUCT

Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors

Julio R. Padilla Carmen Fiuza-luces Alvaro Lassaletta Helios Pareja-galeano Jaime Valentín Antonio Pérez-martínez Elena Santana-sosa Alejandro Santos-lozano Steven J. Fleck Alejandro Lucia Margarita Pérez Luisa Soares-miranda Javier S. Morales Fabian Sanchis-gomar

subject

Male Oncology medicine.medical_specialty Adolescent medicine.medical_treatment Physical fitness Physical Therapy Sports Therapy and Rehabilitation Body Mass Index law.invention 03 medical and health sciences 0302 clinical medicine Immune system Randomized controlled trial law Neoplasms Internal medicine medicine Humans Muscle Strength Exercise physiology Child Educación física Exercise Chemotherapy business.industry Rehabilitation Cancer Resistance Training 030229 sport sciences Cáncer medicine.disease Pediatric cancer Neoadjuvant Therapy Exercise Therapy Killer Cells Natural Treatment Outcome Chemotherapy Adjuvant Physical Fitness 030220 oncology & carcinogenesis Immunology Quality of Life Female business KIR2DS4

description

The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions are safe in pediatric cancer patients with solid tumors during chemotherapy treatment despite its aggressive, immunosuppressive nature. Fondo de Investigaciones Sanitarias PI15/00558 Fondo de Investigaciones Sanitarias PI15/00558; Cátedra Real Madrid-Universidad Europea 2015/02RM, 2016/RM02; Conselleria de Educación, Investigación, Cultura y Deporte de la Generalitat Valenciana APOSTD/2016/140; Ministry of Education, Culture and Sport FPU14/03435; Sara Borrell ISCIII-MINECO-Spain/FEDER-EU CD14/00005 1.843 JCR (2017) Q2, 25/65 Rehabilitation; Q3, 44/81 Sport Sciences 0.636 SJR (2017) Q2, 60/201 Physical Therapy, Sports Therapy and Rehabilitation, 39/125 Rehabilitation; Q3, 68/127 Sports Science No data IDR 2017 UEM

year	journal	country	edition	language
2017-06-24	American Journal of Physical Medicine & Rehabilitation

https://doi.org/10.1097/phm.0000000000000757