6533b852fe1ef96bd12aa3ab
RESEARCH PRODUCT
Investigations Concerning the Correlation of COX-1 Inhibitory and Hydroxyl Radical Scavenging Activity
Werner KieferHolger UlbrichJan-peter KrambGerd DannhardtAndreas MatternMichael Scholzsubject
chemistry.chemical_classificationHydroxyl RadicalRadicalCarboxylic acidPharmaceutical ScienceContext (language use)Free Radical ScavengersInhibitory postsynaptic potentialStructure-Activity Relationshipchemistry.chemical_compoundchemistryDrug DiscoveryCyclooxygenase 1AnimalsOrganic chemistryCattleCyclooxygenase InhibitorsHydroxyl radicalScavengingdescription
The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX-1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-04-12 | Archiv der Pharmazie |