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RESEARCH PRODUCT
Crucial Role of Interleukin-4 in the Survival of Colon Cancer Stem Cells
Jan Paul MedemaGiorgio StassiYlenia LombardoMatilde TodaroMileidys Perez AleaMaria Giovanna Francipanesubject
Cancer ResearchCell SurvivalColorectal cancermedicine.medical_treatmentCancerBiologymedicine.diseaseInterleukin-4 colon cancer stem cellsCytokineOncologyCancer stem cellColonic NeoplasmsImmunologyNeoplastic Stem CellsCancer researchmedicineHumansCytotoxic T cellInterleukin-4Stem cellAutocrine signallingInterleukin 4description
Abstract Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance to clinical cytotoxic therapies and recent work suggests that this resistance may be mediated in part by an autocrine response to the immune cytokine interleukin 4 (IL-4). Blocking IL-4 signaling can sensitize CSCs to apoptotic stimuli and increase the in vivo efficacy of cytotoxic therapy. These findings suggest that inhibitors of IL-4 signaling may offer a new therapeutic tool in colon carcinoma. [Cancer Res 2008;68(11):4022–5]
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 | Cancer Research |