6533b852fe1ef96bd12aadd3
RESEARCH PRODUCT
Candida albicans triggers proliferation and differentiation of hematopoietic stem and progenitor cells by a MyD88-dependent signaling.
Daniel GozalboCelia MurcianoAlberto YáñezM. Luisa GilJosé-enrique O'connorsubject
Cellular differentiationStem CellsImmunologyCell DifferentiationBiologybiology.organism_classificationHematopoietic Stem CellsMicrobiologyMicrobiologyCell biologyEndothelial stem cellMice Inbred C57BLHaematopoiesisMiceInfectious DiseasesCandida albicansMyeloid Differentiation Factor 88AnimalsProgenitor cellStem cellCandida albicansInterleukin 3Adult stem cellCell Proliferationdescription
As TLRs are expressed by hematopoietic stem and progenitor cells, these receptors may play a role in hematopoiesis in response to pathogens during infection. We showed here that inactivated yeasts and hyphae of Candida albicans induce in vitro the proliferation of purified murine hematopoietic stem and progenitor cells (Lin(-)c-Kit(+) Sca-1(+)) as well as their differentiation to lineage positive cells, through a MyD88-dependent pathway. These results indicate that TLR-mediated recognition of C. albicans by hematopoietic stem and progenitor cells may augment the host capability for rapidly replenishing the innate immune system during candidiasis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-04-01 | Microbes and infection |