6533b852fe1ef96bd12ab799
RESEARCH PRODUCT
N‐Heterocyclic Carbene Catalyzed Quadruple Domino Reactions: Asymmetric Synthesis of Cyclopenta[ c ]chromenones
Xiang-yu ChenRakesh PuttreddyQiang LiuKari RissanenDieter Enderssubject
Reaction mechanismCyclopentanes010405 organic chemistryEnantioselective synthesisGeneral ChemistryGeneral MedicineCoumarin010402 general chemistryCombinatorial chemistry01 natural sciencesCatalysisDominoCatalysis0104 chemical scienceschemistry.chemical_compoundchemistryOrganocatalysisCarbenedescription
An N-heterocyclic carbene catalyzed domino sequence via α,β-unsaturated acyl azolium intermediates has been developed. This strategy provides a convenient enantioselective route to functionalized tricyclic coumarin derivatives and cyclopentanes. DFT studies and control experiments were performed to gain better insight into the reaction mechanism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-30 | Angewandte Chemie |