6533b852fe1ef96bd12ab79c
RESEARCH PRODUCT
Poly(ethylene glycol) diacrylate based monolithic capillary columns for the analysis of polar small solutes by capillary electrochromatography
José Manuel Herrero-martínezÓScar Mompó-rosellóErnesto F. Simó-alfonsoMaría Vergara-barberánsubject
chemistry.chemical_classificationCapillary electrochromatographyChemical polarity010401 analytical chemistryFiltration and SeparationEther02 engineering and technology021001 nanoscience & nanotechnology01 natural sciences0104 chemical sciencesAnalytical Chemistrychemistry.chemical_compoundMonomerchemistryChemical engineeringMethanol0210 nano-technologyEthylene glycolAlkylBenzoic aciddescription
Monolithic stationary phases based on poly(ethylene glycol) diacrylates for capillary electrochromatography were developed. Several poly(ethylene glycol) diacrylates (Mn 250, 575, and 700) were used as single monomers and the resulting columns were carefully compared. Methanol and ethyl ether were selected as porogenic solvents, and in all cases ultraviolet radiation was selected as initiation method to prepare polymeric monoliths. The influence of the monomer chain length and ratio monomer/porogen on the morphological and electrochromatographic properties of the resulting monoliths was investigated. Several families of compounds with different polarity (alkyl benzenes, organophosphorous pesticides, benzoic acid derivatives, and sulfonamides) were selected to evaluate the performance of the fabricated monolithic columns. The best results were obtained for poly(ethylene glycol) diacrylate 700 monoliths affording efficiencies of 144 000 plates/m for retained polar aromatic small molecules and excellent reproducibility in column preparation (RSD values below 2.5%).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-05-11 | Journal of Separation Science |