6533b853fe1ef96bd12ac24b
RESEARCH PRODUCT
Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
Susanne HahnToszka BohnHansjörg SchildAlexander UlgesFrauke ZippNadine GrebeTobias BoppAri WaismanSonja ReißigAndreas BeilhackSabine MuthNatascha StergiouSebastian ReuterTill-julius BrühlMatthias KleinMarkus HoffmannOdile Filhol-cochetIrma HabenEdgar SchmittHajime YurugiHans Christian ProbstKrishnaraj RajalingamBrigitte BoldyreffThierry BuchouIris BellinghausenMinka BreloerBastian GerlitzkiHelmut JonuleitAndrea TuettenbergValérie Staudtsubject
CD4-Positive T-LymphocytesMaleT cellImmunologyMice TransgenicReceptors Cell Surfacechemical and pharmacologic phenomenaCell Growth ProcessesT-Lymphocytes RegulatoryCell LineMiceTh2 CellsImmune systemHypersensitivitymedicineAnimalsHumansImmunology and AllergyIL-2 receptorCasein Kinase IIMice Inbred BALB CChemistryPeripheral toleranceFOXP3Cell DifferentiationForkhead Transcription FactorsDendritic CellsAcquired immune systemCell biologyMice Inbred C57BLmedicine.anatomical_structureCell cultureInterferon Regulatory FactorsImmunologyLeukocytes MononuclearIRF4description
The quality of the adaptive immune response depends on the differentiation of distinct CD4(+) helper T cell subsets, and the magnitude of an immune response is controlled by CD4(+)Foxp3(+) regulatory T cells (Treg cells). However, how a tissue- and cell type-specific suppressor program of Treg cells is mechanistically orchestrated has remained largely unexplored. Through the use of Treg cell-specific gene targeting, we found that the suppression of allergic immune responses in the lungs mediated by T helper type 2 (TH2) cells was dependent on the activity of the protein kinase CK2. Genetic ablation of the β-subunit of CK2 specifically in Treg cells resulted in the proliferation of a hitherto-unexplored ILT3(+) Treg cell subpopulation that was unable to control the maturation of IRF4(+)PD-L2(+) dendritic cells required for the development of TH2 responses in vivo.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-08 | Nature Immunology |