6533b853fe1ef96bd12ac34c

RESEARCH PRODUCT

Differential effects of hypothermia on neuronal efflux, release and uptake of noradrenaline

R. LindmarKonrad Löffelholz

subject

medicine.medical_specialtySympathetic nervous systemReserpineSympathetic Nervous SystemStimulationNorepinephrine (medication)NorepinephrineHeart Conduction SystemDesipramineInternal medicinemedicineAnimalsNeuronsPharmacologyChemistryMyocardiumDesipramineTemperatureGeneral MedicineReserpineHypothermiaPargylineStimulation ChemicalCold TemperaturePerfusionEndocrinologymedicine.anatomical_structurePargylineRabbitsEffluxmedicine.symptommedicine.drug

description

Isolated rabbit hearts were perfused at 34° (control), 24° or 12°C. The neuronal efflux of noradrenaline after perfusion with the amine for 1 h was depressed at 24° C (Q 10 about 5) in the presence or absence of desipramine; at 12°C the efflux was below the limit of estimation. Moderate reduction of the temperature (24° C) decreased the removal of perfused noradrenaline to about 60% of the control value and caused a 1.7-fold increase of the output of noradrenaline evoked by sympathetic nerve stimulation. It is concluded that the extremely temperature-dependent efflux of noradrenaline across the axonal membrane is not part of the release of noradrenaline evoked by nerve stimulation.

yearjournalcountryeditionlanguage
1972-01-01Naunyn-Schmiedeberg's Archives of Pharmacology
https://doi.org/10.1007/bf00501278