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RESEARCH PRODUCT
Retinal nerve fibre layer and brain grey substance as early prognostic factors for disability in multiple sclerosis.
Antonio Lleó-pérezMaría José Magraner-benedictoRaquel BañónAna Llorca-cardeñosaMarta J. Llorca-cardeñosaMaria D Pinazo-duransubject
Malemedicine.medical_specialtygenetic structuresAnterior Visual Pathwaymedia_common.quotation_subjectVision DisordersVisual AcuityNerve fibre layerGrey substanceContrast SensitivityCellular and Molecular Neurosciencechemistry.chemical_compoundMultiple Sclerosis Relapsing-RemittingOptical coherence tomographyOphthalmologymedicineContrast (vision)HumansMacula Luteamedia_commonmedicine.diagnostic_testbusiness.industryMultiple sclerosisRetinalAnatomymedicine.diseaseeye diseasesSensory SystemsAxon lossOphthalmologychemistryFemalesense organsbusinessdescription
We read with interest the article by Bock et al ,1 in which the association between retinal nerve fibre layer (RNFL) and total macular volume (TMV) was analysed by optical coherence tomography (OCT) and contrast sensitivity was measured by functional acuity contrast testing in relapsing-remitting multiple sclerosis (MS) patients. The authors found that the functional contrast vision in MS is influenced by morphological changes in the anterior visual pathway. This work emphasised that contrast sensitivity is reduced in MS, and that RNFL and TMV, as morphological measures of retinal axon loss, are predictors of contrast sensitivity. Ophthalmological examinations were the basis of the Bock et al 1 study. There …
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-06-15 | The British journal of ophthalmology |