6533b853fe1ef96bd12acdb9
RESEARCH PRODUCT
Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
Kenneth R. PughXueling ChenXiaoyu WangJianghong HeNicole LandiHan WuRao FuFengyu CongFengyu CongXiaoyu Xiasubject
MaleMismatch negativityPhysiologyMismatch negativityNeuropsychological TestsAudiologyElectroencephalographySeverity of Illness Indexvegetative stateCorrelation0302 clinical medicineLevel of consciousnessDisorder of consciousnessEEGEvoked PotentialsOddball paradigmMinimally conscious stateVegetative statemedicine.diagnostic_testGeneral Neuroscience05 social sciencesMinimally conscious stateElectroencephalographyGeneral MedicineMiddle Agedtajuttomuusdisorder of consciousnessAuditory PerceptionConsciousness DisordersOriginal ArticleFemalePsychologyAdultmedicine.medical_specialtyAdolescentWavelet AnalysisStimulus (physiology)behavioral disciplines and activities050105 experimental psychology03 medical and health sciencesmedicineHumans0501 psychology and cognitive sciencesAgedmedicine.diseaseminimally conscious stateElectrophysiologyAcoustic StimulationBrain Injuriestajunnan tasopoikkeavuusnegatiivisuus030217 neurology & neurosurgerydescription
In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequencydeviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery ScaleRevised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-01 |