6533b853fe1ef96bd12ad44b
RESEARCH PRODUCT
Mesoporous silicate as matrix for drug delivery systems of non-steroidal antinflammatory drugs
F. TestaPaola PierroGaetano GiammonaLuigi PasquaGennara CavallaroRosario Aiellosubject
Drugeducation.field_of_studymedia_common.quotation_subjectPopulationDiflunisalPharmacologyCombinatorial chemistrySilicateMatrix (mathematics)chemistry.chemical_compoundchemistryOral administrationDrug deliverymedicineeducationMesoporous silicatemedia_commonmedicine.drugdescription
Publisher Summary The suitability of a mesoporous silicate matrix as a drug-delivery system has been evaluated using different nonsteroid anti-inflammatory agents as model drugs. This type of matrix can trap the bioactive agents by a soaking procedure and then release them in conditions mimicking the biological fluids. The high affinity of these matrices for water makes them potentially biocompatible. A matrix impregnated with diflunisal can offer a good potential as a system for the controlled drug release. In fact, only 20% of the drug is released at the gastric level allowing, in this way, the reduction of side effects related to the oral administration of nonsteroidal anti-inflammatory agents and the release of the most part of drug in the intestinal duct. In this regard, hydroxyl population that is responsible for the interaction between the drug and the silicate surface depends on the activation method.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-01-01 |