6533b853fe1ef96bd12ad4b7

RESEARCH PRODUCT

Influence of Agents Used for Topical Wound Treatment on Phagocyte Stimulation and Fibroblast Growth

B. MorschesG. KlinkeR. E. SchopfM. Rehder

subject

PhagocyteSuperoxideGranulation tissueGranulocyteMicrobiologyRespiratory burstchemistry.chemical_compoundmedicine.anatomical_structurechemistryImmunologymedicineTumor necrosis factor alphaFibroblastWound healing

description

Wound healing has always been a fascinating phenomenon for physicians and surgeons. Wounds usually close by forming new granulation tissue, contracting, and re-epithelializing. Before granulation begins, polymor-phonuclear leukocytes (PMNs) and monocytes/macrophages (MCs) are chemotactically attracted to sites of injury. Upon contact with various stimuli in the wound including bioactive lipids, complement components, certain cytokines, e.g., tumor necrosis factor-α (TNF-α) [1], granulocyte/ monocyte-colony stimulating factor (GM-CSF), interferon-γ (IFN-γ), and interleukin-8, and particles such as microorganisms, phagocytes respond by a respiratory burst consisting of a markedly enhanced uptake of oxygen, activation of the hexose monophosphate shunt, and generation of oxygen intermediates comprising Superoxide anion, hydrogen peroxide, hydroxyl radical and singlet oxygen [1, 2]. These compounds are able to kill microorganisms and to destroy tissue resulting in wound decontamination and wound debridement (summarized in [3]).

yearjournalcountryeditionlanguage
1995-01-01
https://doi.org/10.1007/978-3-642-77882-7_62