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RESEARCH PRODUCT
Allergy to Polyethilenglicole of Anti-SARS CoV2 Vaccine Recipient: A Case Report of Young Adult Recipient and the Management of Future Exposure to SARS-CoV2
Ignazio BruscaRosa OnidaMaurizio RaineriVincenzo RestivoMaria BarraleSalvatore TiralongoEster CaravelloGiuseppina CandoreGiorgio Grazianosubject
medicine.medical_specialtyAllergyImmunologyadverse reactionCase ReportVial03 medical and health sciences0302 clinical medicineInternal medicinevaccineDrug DiscoverymedicineanaphylaxisPharmacology (medical)030212 general & internal medicineAdverse effectContraindicationDexamethasonePharmacologym-RNA vaccinebusiness.industrySARS CoV2Rmedicine.diseasePEGAdverse reaction Anaphylaxis Basophil activation test Contraindica-tion M-RNA vaccine PEG SARS CoV2 VaccineVaccinationInfectious Diseases030228 respiratory systembasophil activation testMedicinebusinessAnaphylaxisAdverse drug reactioncontraindicationmedicine.drugdescription
The main contraindication to the anti-SARS CoV2 vaccine is an anaphylactic reaction to a vaccine component. The need to vaccinate allergic people who are at higher risk can be of public health interest and this report shows a case of an allergic reaction to PEG of a HCW who had received the first dose of anti-SARS CoV2 vaccine. For 5 h after the administration of the vaccine, she had the appearance of erythematous spots on the face and neck, and a feeling of a slurred mouth and hoarseness. In order to treat the event, she was administered 8 mg intravenous dexamethasone, 1 vial intravenous chlorphenamine maleate, 250 mL intravenous 0.9% NaCl, and conventional oxygen therapy (2 L/min) with complete resolution of the suspected adverse drug reaction. According to the contraindication to the cutaneous test for this patient, BAT was used for further investigations. The patient who suffered the adverse reaction to the COVID-19 vaccine and other five allergic patients who did not report any adverse reaction after the vaccination were tested. There was a significant activation of the vaccine-reactive patient’s basophils with 14.79 CD203chigh% at the concentration of 0.2 mg/mL, while other patients were negative. People who have a confirmed reaction to a vaccine component should undergo further investigation to discover other possible cross-reactions and select the right vaccine to immunize them.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 | Vaccines |