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RESEARCH PRODUCT
Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.
Joseph VijaiW. Ryan DiverDegui ZhiBrenda M. BirmannHenrik HjalgrimBruce K. ArmstrongGianluca SeveriGianluca SeveriPierluigi CoccoJoseph F. FraumeniXifeng WuGraham G. GilesGraham G. GilesEleanor KaneHerve GhesquieresEve RomanEdward GiovannucciMads MelbyeMads MelbyeRudolph KaaksLindsay M. MortonNicholas K. AkersElizabeth A. HollyLiming LiangPatrizio MazzaKari E. NorthJohn J. SpinelliCarrie A. ThompsonBodil OhlssonYuanqing YeAnneclaire J. De RoosAnneclaire J. De RoosStephen J. ChanockTheodore R. HolfordPaul BrennanJianjun LiuRoel VermeulenThomas E. WitzigAngela Brooks-wilsonAngela Brooks-wilsonMark P. PurdueAhmet DoganGilles SallesGilles SallesKenneth OffitLucia CondeLucia CondeLaurie BurdettGeorge J. WeinerAnne KrickerJames MckayPeter KraftSonja I. BerndtAttilio GabbasRebecca MontalvanRebecca D. JacksonBaoshan MaBaoshan MaZhaoming WangPatricia HartgeDanylo J. VillanoMarc MaynadieMortimer J. LacherLauren R. TerasSusan L. SlagerLenka ForetovaRachel S. KellyRachel S. KellyMartha S. LinetBrian K. LinkJarmo VirtamoCharles C. ChungAnne Zeleniuch-jacquotteMartyn T. SmithTracy LightfootJacques RibyJacques RibyPaolo BoffettaMeredith YeagerBrian C.-h. ChiuGrzegorz S. NowakowskiYolanda BenaventeBengt GlimeliusBengt GlimeliusMark LiebowSaioa ChamosaCharles E. LawrenceKarin E. SmedbyNikolaus BeckerThomas M. HabermannJacqueline ClavelJacqueline ClavelQing LanAlexandra NietersMaryjean SchenkSophia S. WangDemetrius AlbanesLesley F. TinkerAlex SmithAnthony StainesAmy HutchinsonWendy CozenHans-olov AdamiHans-olov AdamiAnne J. NovakChristine F. SkibolaChristine F. SkibolaAnn MariaElisabete WeiderpassKimberly A. BertrandJames R. CerhanMaria Grazia EnnasClaire M. VajdicJinyan HuangPaul I.w. De BakkerPaige M. BracciTongzhang ZhengRuth C. TravisPaolo VineisJia Nee FooJennifer TurnerAlain MonnereauAlain MonnereauSilvia De SanjoséNathaniel RothmanYawei ZhangJian Gusubject
EXPRESSIONFollicular lymphomaSingle-nucleotide polymorphismGenome-wide association studyHuman leukocyte antigenBiologyVARIANTSPolymorphism Single Nucleotidefollicular lymphomaHLA AntigensPolymorphism (computer science)ReportCLASS-IRESOURCEBiomarkers TumorGeneticsmedicineChromosomes HumanHumansTOOLGenetic Predisposition to DiseaseGenetics(clinical)PEPTIDEAlleleLymphoma FollicularAllelesGenetics (clinical)Genetic associationSNPSGeneticsRISKGenome-wide associationHaplotypemedicine.diseaseHLAHaplotypesCase-Control StudiesUNIVERSITYSETGenome-Wide Association Studydescription
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10 -20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10 -11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10 -10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10 -10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10 -8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRß1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10 -67 to 2.67 × 10 -70). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10 -16) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10 -9). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. © 2014 by The American Society of Human Genetics. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-02 |