6533b853fe1ef96bd12ad76e

RESEARCH PRODUCT

Permeability of the rat bladder to Cisplatinum under different conditions: comparison with Mitomycin C and Adriamycin.

G. OelsnerR. A. BürgerU. EngelmannH. Wagner

subject

Antibiotics AntineoplasticChemistryUrologymedicine.medical_treatmentMitomycinMitomycin CBladder MucosaUrinary BladderRats Inbred StrainsPharmacologySerum concentrationElectrocoagulationPermeabilityMitomycinsRatsPulmonary surfactantDoxorubicinAnesthesiaCystitismedicineElectrocoagulationAnimalsCisplatinRat Bladder

description

In 50 female Sprague-Dawley rats the absorption of Cisplatinum through the bladder wall was studied. Under different conditions, including cystitis and electrocoagulation of the bladder mucosa, the absorption was low and the measureable serum concentrations did not exceed 2.64 micrograms/ml. The influence of Tween 80--a non-ionic surfactant--on the absorption is investigated. The results are compared with those found for Adriamycin and Mitomycin C under identical conditions.

yearjournalcountryeditionlanguage
1983-03-01Urological research
10.1007/bf00272708https://pubmed.ncbi.nlm.nih.gov/6407169