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RESEARCH PRODUCT
Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid–Base Status and Kidney Function at Rest and during Submaximal Cycling
Johanna K IhalainenDaniela EklundH. PitkänenAntti A. MeroMoritz SchumannLynda A. FrassettoEnni-maria HietavalaKeijo Häkkinensubject
Maleand promotion of well-beingKidney DiseasekestävyysharjoitteluPhysiology030204 cardiovascular system & hematologyKidneyruokavaliotchemistry.chemical_compound0302 clinical medicinedietary acid loadYoung adultta315kidney functionmunuaisetAcid-Base EquilibriumKidneyNutrition and Dieteticsdietary acid load; acid–base status; net acid excretion; exercise training; kidney functionHydrogen-Ion ConcentrationMiddle Agedmedicine.anatomical_structureacid–base statusFemaleCyclinglcsh:Nutrition. Foods and food supplyAdultBicarbonateacid-base statusRenal and urogenitalhappo-emästasapainoRenal functionlcsh:TX341-641Acid–base homeostasisnet acid excretionArticleYoung Adult03 medical and health sciencesFood SciencesClinical ResearchComplementary and Integrative HealthmedicineHumans3.3 Nutrition and chemopreventionMetabolic and endocrineNutrition6.7 PhysicalTraining periodbusiness.industryPreventionEvaluation of treatments and therapeutic interventionsResistance Training030229 sport sciencesPrevention of disease and conditionsDietchemistryExercise TestPhysical EnduranceNet acid excretionbusinessexercise trainingFood AnalysisFood Sciencedescription
Prolonged effects of dietary acid intake on acid–base status and kidney function have not yet been studied in an intervention study in healthy subjects. Dietary acid load can be estimated by calculating the potential renal acid load (PRAL) of foods. Effects of low-PRAL and moderate-PRAL diets on acid–base status and kidney function were investigated during a 12-week exercise training period. Healthy, 20–50-year-old men (n = 21) and women (n = 25) participated in the study and were randomly divided into low-PRAL and moderate-PRAL groups. Before (PRE), mid-phase (MID) and after the intervention (POST), the subjects participated in measurement sessions, where a 12-h urine sample and fasting blood samples were collected, and a submaximal cycle ergometer test was performed. Net acid excretion was significantly lower after 12 weeks of the low-PRAL diet as compared to the moderate-PRAL diet, both in men and women. In low-PRAL females, capillary pH and bicarbonate were significantly higher at 75% of VO2max at POST as compared to PRE. Glomerular filtration rate decreased over the study period in moderate-PRAL men and women. The results of the present study suggest that an acidogenic diet and regularly training together may increase the acidic load of the body and start to impair the kidney function in recreationally active subjects. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-03-08 | Nutrients; Volume 10; Issue 3; Pages: 323 |