6533b854fe1ef96bd12ae870
RESEARCH PRODUCT
Thiophene series. Substituent effect on thiophenoxy debromination of various 2-nitro-3-bromo-5-X-thiophenes
Domenico SpinelliGiuseppe GuantiC. Dell’erbasubject
SodiumOrganic ChemistryKineticsHeteroatomSubstituentchemistry.chemical_elementRing (chemistry)Medicinal chemistrychemistry.chemical_compoundchemistryNitroThiopheneOrganic chemistryMethanoldescription
The kinetics of the reaction of a series of 2-nitro-3-bromo-5-X-thiophenes with sodium thiophenoxide in methanol were determined. The plot of log k against σ-values gave ρ-value + 4.51 at 20°. Good correlation was observed pointing out the validity of the Hammett relationship for reactions occurring directly on the thiophene ring at the β-position with respect to the heteroatom.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1970-12-01 | Journal of Heterocyclic Chemistry |