6533b854fe1ef96bd12aeab0

RESEARCH PRODUCT

A replication study on P300 single trial analysis in schizophrenia: confirmation of a reduced number of 'true positive' P300 waves.

Joachim RöschkeKlaus MannP. WagnerMichael Grözinger

subject

AdultMalePsychosisBasal (phylogenetics)Replication (statistics)medicineHumansFalse Positive ReactionsBiological PsychiatryBrainCognitionMiddle Agedmedicine.diseaseP300 amplitudeEvent-Related Potentials P300Psychiatry and Mental healthElectrophysiologySchizophreniaCase-Control StudiesAuditory PerceptionEvoked Potentials AuditorySchizophreniaFemaleSingle trialPsychologyNeuroscience

description

A single trial analysis of event-related potentials (auditory odd-ball paradigm) of 20 schizophrenics was performed in comparison to matched healthy controls. The purpose of the study was to test the hypothesis that in schizophrenia the well-known P300 amplitude reduction of averaged event-related potentials is due to fewer elicited single trial P300 waves. The results of the present study support this finding of our previous exploratory investigation and point to the view that schizophrenics reveal basal disturbances in information processing due to inadequately elicited electrophysiological responses to target stimuli.

yearjournalcountryeditionlanguage
2000-06-27Journal of psychiatric research
10.1016/s0022-3956(00)00010-8https://pubmed.ncbi.nlm.nih.gov/10867121