6533b854fe1ef96bd12af4a0
RESEARCH PRODUCT
Experiments on the metyrapone reducing microsomal enzyme system.
G. F. Kahlsubject
PharmacologyMetyrapone reductasemedicine.medical_specialtyMetyraponeChemistryMetaboliteGeneral Medicinechemistry.chemical_compoundEndocrinologyEnzyme systemInternal medicineRat livermedicineMicrosomeAnimalsChromatography Thin LayerIntracellularDrug metabolismmedicine.drugdescription
The formation of reduced metyrapone [2-methyl-1.2-bis-(3-pyridyl)-1-propanol] from metyrapone [2-methyl-1.2-bis-(3-pyridyl)-1-propanone] in the liver has been studied. Reduced metyrapone appeared as the main metabolite of metyrapone in the isolated perfused rat liver. Experiments on the intracellular distribution of the metyrapone reducing activity revealed that metyrapone reductase is mainly localized in the microsomal fraction. In the 105,000 × g supernatant only a little activity was found.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1970-01-01 | Naunyn-Schmiedebergs Archiv fur Pharmakologie |