6533b855fe1ef96bd12afe97

RESEARCH PRODUCT

Chronic hepatitis B in Italy: New features of an old disease - Approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection

Evangelista SagnelliTommaso StroffoliniAlfonso MeleMichele ImparatoPiero L. AlmasioA. TraversoA. ArrigoniM. TorchioP. GarbagnoliB. Del MastroP. RomanoR. VanniD. BrusitaP. MeucciG. CassolaM. BorzioA. BellobuonoA. De BonaT. ReP. Del PoggioO. BaisiniA. ColomboC. AttoliniD. SacchiniL. MinoliV. GazzanigaS. SegatoM. OrioloA. ParlottoM. GhersettiF. CapraR. MuratoriC. SamaS. BocciaG. VerdianelliA. PraticòM. GrandiE. VenturaF. CantoniA. VincentiA. Nerli AlessandroL. GaleazziA. SolinasM. ParoliG. M. De SanctisS. SerenoC. ClementiU. Visco ComandinoA. I. GalloD. FestiG. SabuscoN. CoppolaC. ScolasticoM. OnofrioP. FilippiniF. MoriscoA. LibertiG. BorgiaF. ScarpellinoM. PersicoC. SagnelliC. CoppolaL. CasertaA. EliaG. De VitaA. LanzottiL. PizzolanteV. MessinaG. FioreE. AgostinacchioT. SantantonioM. MazzolaF. VinelliA. CampagnaS. CataldiniI. MonelliM. LascaroN. PolimeriP. FrugiueleM. FerraroT. PrestileoA. AlessandriM. RusselloP. BellissimaG. OrificiG. PisaniS. AngioiniM. LaiM. Spanneda

subject

Liver CirrhosisAdultMaleMicrobiology (medical)medicine.medical_specialtyCirrhosisAdolescentHepatitis D ChronicHepatitis C virusHepacivirusLiver CirrhosiHepacivirusmedicine.disease_causeGastroenterologyVirusFlaviviridaeHepatitis B ChronicSeroepidemiologic StudiesInternal medicinemedicineHumansHepatitis B e AntigensAgedAged 80 and overCross-Sectional StudieHepacivirubiologybusiness.industrySeroepidemiologic StudieHepatitis Delta ViruHepatitis BMiddle Agedmedicine.diseasebiology.organism_classificationHepatitis DVirologyAlcoholismCross-Sectional StudiesInfectious DiseasesItalyDisease ProgressionFemaleHepatitis B e AntigenHepatitis D virusHepatitis Delta VirusbusinessHuman

description

We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis. © 2007 by the Infectious Diseases Society of America. All rights reserved.

yearjournalcountryeditionlanguage
2008-01-04
10.1086/524074http://hdl.handle.net/11585/631993