6533b855fe1ef96bd12aff4d
RESEARCH PRODUCT
Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium
Philipp TrojanSebastian RauschAlexander PulvermüllerUwe WolfrumAndreas Gießlsubject
Gene isoformPhotoreceptorsgenetic structuresPhotoreceptor cellHeterotrimeric G proteinConnecting ciliummedicineCentrinBasal bodyAnimalsPhotoreceptor CellsCiliaTransducinPhosphorylationVision OcularCentrosomeRetinaChemistryLight-dependent translocationCiliumCalcium-Binding ProteinsSensory SystemsCell biologyProtein TransportOphthalmologymedicine.anatomical_structureCentrinVertebratesTransducinsense organsPhotic Stimulationdescription
Centrins are members of a highly conserved subgroup of the EF-hand superfamily of Ca(2+)-binding proteins commonly associated with centrosome-related structures. In the retina, centrins are also prominent components of the photoreceptor cell ciliary apparatus. Centrin isoforms are differentially localized at the basal body and in the lumen of the connecting cilium. All molecular exchanges between the inner and outer segments occur through this narrow connecting cilium. Ca(2+)-activated centrin isoforms bind to the visual heterotrimeric G-protein transducin via an interaction with the betagamma-subunit. Ca(2+)-dependent assemblies of centrin/G-protein complexes may regulate the transducin movement through the connecting cilium. Formation of this complex represents a novel mechanism in regulation of translocation of signaling proteins in sensory cells, as well as a potential link between molecular trafficking and signal transduction in general.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-12-01 | Vision Research |