6533b855fe1ef96bd12aff9b
RESEARCH PRODUCT
Reinforced cyclam derivatives functionalized on the bridging unit
Christine GozeClaire BernhardFrédéric BoschettiNicolas SokYoann RousselinIsabelle BaglinFranck Denatsubject
CyanideRadiometals010402 general chemistry01 natural sciencesCatalysisCopper(ii) complexesCoordination complexContinuous symmetry measureschemistry.chemical_compoundNucleophileBifunctional chelator[SDV.IDA]Life Sciences [q-bio]/Food engineeringCyclamMaterials ChemistryOrganic chemistryMoietyChelationBifunctionalPolyhedrachemistry.chemical_classification010405 organic chemistry[ SDV.IDA ] Life Sciences [q-bio]/Food engineeringGeneral ChemistryCombinatorial chemistry0104 chemical sciencesCoordination chemistrychemistryAminalTherapyStabilitydescription
International audience; A new synthetic method has been developed for the preparation of reinforced cyclams (1,4,8,11-tetraazacyclotetradecane) C-functionalized on the bridging unit, by using a "one pot" reaction starting from the appropriate bis-aminal cyclam intermediate. The high reactivity of quaternized aminal moiety toward nucleophilic agent has been used to elaborate a new class of cross-bridged and side-bridged cyclam derivatives containing cyanide group on the ethylene bridge. Several chelators and corresponding copper(II) complexes have been prepared and characterized by X-ray diffraction. These new constrained polyazamacrocycles are valuable precursors of bifunctional chelating agents for the preparation of PET radiotracers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 |