6533b855fe1ef96bd12b087f

RESEARCH PRODUCT

Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

Maria Letizia MancaIris UsachJosé Esteban PerisMaria ManconiMatteo AroffuElisabetta MargarucciElisabetta MargarucciCarla CaddeoGiacomo Luigi Petretto

subject

liposomesGeneral Chemical Engineering02 engineering and technologyyeastmedicine.disease_causeCitralArticlelaw.inventionlcsh:ChemistryTerpene03 medical and health scienceschemistry.chemical_compoundlawmedicineGeneral Materials ScienceFood sciencebacteriaCandida albicanscitralEssential oil030304 developmental biology0303 health sciencesbiologyChemistryVesiclepompia essential oilfood and beverages021001 nanoscience & nanotechnologyAntimicrobialbiology.organism_classificationlcsh:QD1-999Staphylococcus aureus0210 nano-technologyAntibacterial activity

description

Citrus species extracts are well known sources of bio-functional compounds with health-promoting effects. In particular, essential oils are known for their antibacterial activity due to the high content of terpenes. In this work, the steam-distilled essential oil from the leaves of Citrus limon var. pompia was loaded in phospholipid vesicles. The physico-chemical characteristics of the essential oil loaded vesicles were compared with those of vesicles that were loaded with citral, which is one of the most abundant terpenes of Citrus essential oils. The biocompatibility of the vesicles was assessed in vitro in human keratinocytes. Furthermore, the antimicrobial activity of the vesicles was tested while using different bacterial strains and a yeast: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, respectively. The vesicles were small in size (~140 nm), slightly polydispersed (PI ~0.31), highly negatively charged (~ &minus

yearjournalcountryeditionlanguage
2020-02-01Nanomaterials
https://doi.org/10.3390/nano10020286