6533b855fe1ef96bd12b0996

RESEARCH PRODUCT

Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma

Giuseppe MontaltoM. La RosaMonica NotarbartoloLucrezia VirrusoNatale D'alessandroMaurizio SoresiLydia GiannitrapaniM. Cervello

subject

MaleReceptor complexCarcinoma HepatocellularHepatocellular carcinomaGeneral Biochemistry Genetics and Molecular BiologySignal transduction proteingp130History and Philosophy of SciencemedicineCarcinomaHumansReceptorBiochemistry Genetics and Molecular Biology (all)medicine.diagnostic_testbusiness.industryInterleukin-6General NeuroscienceLiver NeoplasmsAcute-phase proteinMiddle Agedmedicine.diseaseGlycoprotein 130Receptors Interleukin-6Hepatocellular carcinomaLiver function testCancer researchFemaleSignal transductionLiver function testsbusinessReceptor

description

Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.

yearjournalcountryeditionlanguage
2002-07-04
http://hdl.handle.net/10447/198026