6533b855fe1ef96bd12b0aea

RESEARCH PRODUCT

PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling

Erica L. JacksonArturo Alvarez-buyllaMonica RoyScott R. VandenbergSara Gil-perotinJosé Manuel García-verdugoAlfredo Quiñones-hinojosa

subject

Receptor Platelet-Derived Growth Factor alphaAdolescentNeuroscience(all)Subventricular zoneMice TransgenicDEVBIOBiologyMOLNEUROMiceNeuroblastLateral VentriclesmedicineAnimalsHumansCell ProliferationAged 80 and overNeuronsPlatelet-Derived Growth FactorStem CellsGeneral NeuroscienceNeurogenesisGliomaMiddle AgedSTEMCELLOligodendrocyteNeural stem cellCell biologymedicine.anatomical_structurenervous systemNeuronStem cellNeuroscienceSignal TransductionAdult stem cell

description

Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRalpha in the adult SVZ. Specifically labeled PDGFRalpha expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRalpha in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRalpha signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages of tumor formation.

yearjournalcountryeditionlanguage
2006-07-01Neuron
10.1016/j.neuron.2006.06.012http://dx.doi.org/10.1016/j.neuron.2006.06.012