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RESEARCH PRODUCT
Representation of time intervals in the right posterior parietal cortex: implications for a mental time line
Emanuele Lo GerfoGiacomo KochSara TorrieroCarlo CaltagironeMassimiliano OliveriSilvia Salernosubject
AdultMalemedicine.medical_specialtyCognitive NeuroscienceBisectionmedicine.medical_treatmentPosterior parietal cortexCognitive neuroscienceAudiologyBrain Mapping; Image Interpretation Computer-Assisted; Humans; Adult; Time Perception; Space Perception; Transcranial Magnetic Stimulation; Parietal Lobe; Male; Functional Laterality; Femalebehavioral disciplines and activitiesBrain mappingFunctional LateralityNOComputer-Assisted Image InterpretationComputer-AssistedParietal LobeImage Interpretation Computer-AssistedmedicineSPACEHumansImage InterpretationBrain MappingSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaNeuropsychologyParietal lobeTranscranial Magnetic Stimulation; Computer-Assisted Image Interpretation; Time Perception; Space Perception; Parietal Lobe; Functional Laterality; Brain MappingTime perceptionTranscranial Magnetic StimulationTIMETranscranial magnetic stimulationNeurologyNEGLECTTMSSpace PerceptionTime PerceptionFemaleSettore MED/26 - NeurologiaPsychologypsychological phenomena and processesHumanCognitive psychologydescription
Space and time interact with each other in the cognitive system. Recent studies indicate the posterior parietal cortex (PPC) as the neural correlate of spatial-temporal interactions. We studied whether the contribution of the PPC becomes critical in tasks requiring the performance of spatial computations on time intervals. We adopted an integrated neuropsychological and transcranial magnetic stimulation (rTMS) approach, presenting behavioural timing tasks to both healthy subjects and right-brain-damaged patients with and without evidence of spatial neglect. rTMS of the right PPC of healthy subjects induced a lateralised bias during a task requiring setting the midpoint of a time interval. This bias mimicked the rightward bias observed in tasks requiring setting the midpoint of line intervals. These effects were selectively encountered when rTMS was applied during the retrieval phase of the task, while no effects were observed during the initial encoding phase of the time interval. Similar effects were also observed during bisection of time intervals by right-brain-damaged patients with spatial neglect. The specific role of the right PPC in bisection of physical intervals was confirmed by an experiment in which line segments were used. These findings document the neural correlates of spatial-temporal interactions and argue for a linear metric representation of time intervals. © 2009 Elsevier Inc. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |