6533b856fe1ef96bd12b1e8c

RESEARCH PRODUCT

Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer’s Disease: Clinical and FDG-PET Correlation

Vanesa PytelMaría Nieves Cabrera-martínCarmen GarridoCarmen GarridoTeresa Moreno-ramosMarine CordonnierMarine CordonnierJessica GobboGaëtan ChanteloupGaëtan ChanteloupJordi A. Matías-guiuUlises Gómez-pinedoJorge Matías-guiu

subject

Male0301 basic medicineOncologymedicine.medical_specialtyDiseaseNeuropsychological TestsExosomesCorrelation03 medical and health sciences0302 clinical medicineAlzheimer DiseaseFluorodeoxyglucose F18Internal medicinemental disordersmedicineHumansHSP70 Heat-Shock ProteinsCorrelation of DataAgedbusiness.industryGeneral NeuroscienceNeurodegenerationGeneral Medicinemedicine.diseaseMicrovesiclesHsp70Psychiatry and Mental healthClinical Psychology030104 developmental biologyFrontotemporal DementiaPositron-Emission TomographyCohortFemaleRadiopharmaceuticalsGeriatrics and GerontologybusinessBiomarkers030217 neurology & neurosurgeryFrontotemporal dementia

description

We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.

yearjournalcountryeditionlanguage
2019-10-15Journal of Alzheimer's Disease
https://doi.org/10.3233/jad-190545