6533b856fe1ef96bd12b1f09
RESEARCH PRODUCT
Increased prolyl 4-hydroxylase activity in the myocardium of endurance-trained mice.
I. HassinenT. E. S. TakalaHeikki KainulainenVeikko VihkoR Myllylasubject
Malemedicine.medical_specialtyHeart VentriclesProcollagen-Proline DioxygenaseBiologyCellular and Molecular NeuroscienceHydroxyprolinechemistry.chemical_compoundMiceEndurance trainingInternal medicinemedicineAnimalsMolecular BiologyPharmacologychemistry.chemical_classificationMyocardiumCell BiologyOrgan SizeHydrogen-Ion ConcentrationGalactosylhydroxylysyl glucosyltransferaseEnzymemedicine.anatomical_structureEndocrinologychemistryVentricleGlucosyltransferasesPhysical EnduranceMolecular Medicinedescription
Endurance training over 3, 10 or 20 days increased the activity of prolyl 4-hydroxylase (PH) in the left ventricle of mice. No increase was observed in the weight of the left ventricle, in galactosylhydroxylysyl glucosyltransferase activity or in hydroxyproline concentration. The increase in PH suggests that the synthesis of collagen increases during physiological adaptation of the heart to endurance exercise without changes in the ventricle weight or its total collagen content.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1983-10-15 | Experientia |