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RESEARCH PRODUCT

Neurochemical correlates of brain atrophy in fibromyalgia syndrome: a magnetic resonance spectroscopy and cortical thickness study

Paola Feraco 12Salvatore Nigro 3Luca Passamonti 45Alessandro Grecucci 6Maria Eugenia Caligiuri 3Cesare Gagliardo 7Antonella Bacci 8

subject

In vivo magnetic resonance spectroscopymedicine.medical_specialtybrain MRIArticlelcsh:RC321-57103 medical and health sciences0302 clinical medicineNeurochemicalAtrophyNeuroimagingGyrusFibromyalgiaInternal medicinemedicinecortical thicknelcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biology0303 health sciencesbusiness.industryGeneral NeuroscienceMR spectroscopyGlutamate receptorSettore MED/37 - Neuroradiologiacortical thicknessmedicine.diseaseSubcortical gray matterEndocrinologymedicine.anatomical_structurefibromyalgia; glutamate excitotoxicity; cortical thickness; brain MRI; chronic pain; MR spectroscopyMR spectroscopy; brain MRI; chronic pain; cortical thickness; fibromyalgia; glutamate excitotoxicity.fibromyalgiaSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusinesschronic pain030217 neurology & neurosurgeryglutamate excitotoxicity

description

(1) Background: Recently, a series of clinical neuroimaging studies on fibromyalgia (FM) have shown a reduction in cortical volume and abnormally high glutamate (Glu) and glutamate + glutamine (Glx) levels in regions associated with pain modulation. However, it remains unclear whether the volumetric decreases and increased Glu levels in FM are related each other. We hypothesized that higher Glu levels are related to decreases in cortical thickness (CT) and volume in FM patients. (2) Methods: Twelve females with FM and 12 matched healthy controls participated in a session of combined 3.0 Tesla structural magnetic resonance imaging (MRI) and single-voxel MR spectroscopy focused on the thalami and ventrolateral prefrontal cortices (VLPFC). The thickness of the cortical and subcortical gray matter structures and the Glu/Cr and Glx/Cr ratios were estimated. Statistics included an independent t-test and Spearman&rsquo

yearjournalcountryeditionlanguage
2020-06-20
10.3390/brainsci10060395https://www.mdpi.com/2076-3425/10/6/395