6533b856fe1ef96bd12b278d

RESEARCH PRODUCT

Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study

Stefano AlibertiLuis F ReyesPaola FaverioGiovanni SotgiuSimone DoreAlejandro H RodriguezNilam SoniMarcos I RestrepoPatricia Karina ArujSilvia AttorriEnrique BarimboimJuan Pablo CaeiroMaría I GarzónVictor Hugo CambursanoAdrian CeccatoJulio ChertcoffFlorencia LascarFernando Di TulioAriel Cordon DíazLautaro De VediaMaria Cristina GanahaSandra LambertGustavo LopardoCarlos M LunaAlessio Gerardo MalbertiNora MorcilloSilvina TartaraClaudia PensottiBetiana PereyraPablo Gustavo ScapellatoJuan Pablo StagnaroSonali ShahFelix LötschFlorian ThalhammerJean Louis VincentKurt AnseeuwCamille A FrancoisEva Van BraeckelMarcel Zannou DjimonJules BashiRoger DodoSimone Aranha NouérPeter ChipevMilena EnchevaDarina MitevaDiana PetkovaAdamou Dodo BalkissouEric Walter Pefura YoneBertrand Hugo Mbatchou NgahaneNing ShenJin-fu XuCarlos Andres Bustamante RicoRicardo BuitragoFernando Jose Pereira PaterninaJean-marie Kayembe NtumbaVesna Vladic CarevicMarko JakopovicMateja JankovicZinka MatkovicIvan MitrecicMarie-laure Bouchy JacobssonAnette Bro ChristensenUffe Christian Heitmann BødtgerChristian Niels MeyerAndreas Vestergaard JensenGertrud Baunbæk-knudsenPelle Trier PetersenStine AndersenIbrahim El-said Abd El-wahhabNesreen Elsayed MorsyHanaa ShafiekEman SobhKedir Abdella AbdulsemedFabrice BertrandChristian Brun-buissonEtienne De MontmollinMuriel FartoukhJonathan MessikaPierre TattevinAbdo KhouryBernard EbrukeMichael DreherMartin KolditzMatthias MeisingerMathias W PletzStefan HagelJan RuppTom SchabergMarc SpielmannsPetra CreutzNorton SuttorpBeatrice Siaw-larteyKaterina DimakouDimosthenis PapapetrouEvdoxia TsigouDimitrios AmpazisEvaggelos KaimakamisMohit BhatiaRaja DharGeorge D'souzaRajiv GargParvaiz A KoulP A MaheshB S JayarajKiran Vishnu NarayanHirennappa B UdnurShashi Bhaskara KrishnamurthySurya KantRajesh SwarnakarSneha LimayeSundeep SalviKeihan GolshaniVera M KeatingsIgnacio Martin-loechesYasmin MaorJacob StrahilevitzSalvatore BattagliaMaria CarrabbaPiero CerianaMarco ConfalonieriAntonella D'arminio MonforteBruno Del PratoMarino De RosaRiccardo FantiniGiuseppe FiorentinoMaria Antonia GamminoFrancesco MenzellaGiuseppe MilaniStefano NavaGerardo PalmieroRoberta PetrinoBarbra GabrielliPaolo RossiClaudio SorinoGundi SteinhilberAlessandro ZanforlinFabio FranzettiManuela CarugatiManuela MorosiElisa MongeMauro CaroneVincenzo PatellaSimone ScarlataAndrea ComelKiyoyasu KurahashiZeina Aoun BachaDaniel Barajas UgaldeOmar Ceballos ZuñigaJosé F VillegasMilic MedenicaE M W Van De GardeDeebya Raj MihsraPoojan ShresthaElliott RidgeonBabatunde Ishola AwokolaOgonna N O NwankwoAdefuye Bolanle OlufunlolaSegaolu OlumideKingsley N UkwajaMuhammad IrfanŁUkasz MinarowskiSkoczynski SzymonFelipe FroesPedro LeuschnerMariana MeirelesCláudia FerrãoPedro LeuschnerJoão NevesSofia B RavaraVictoria BrocovschiiChesov IonDoina RusuCristina TomaDaniela ChiritaCarmen Mihaela DorobatAlexei BirkunAnna KaluzheninaAbdullah AlmotairiZakeya Abdulbaqi Ali BukharyJameela EdathoduAmal FathyAbdullah Mushira Abdulaziz EnaniNazik Eltayeb MohamedJawed Ulhadi MemonAbdelhaleem BellaNada BogdanovicBranislava MilenkovicDragica PesutLuis BorderìasNoel Manuel Bordon GarciaHugo Cabello AlarcónCatia CillonizAntoni TorresVicens Diaz-britoXavier CasasAlicia Encabo GonzálezMaria Luisa Fernández-almiraMiguel GallegoInmaculada Gaspar-garcíaJuan González Del CastilloPatricia Javaloyes VictoriaElena Laserna MartínezRosa Malo De MolinaPedro J MarcosRosario MenéndezAna Pando-sandovalCristina Prat AymerichAlicia Lacoma De La TorreIgnasi García-olivéJordi RelloSilvia MoyanoFrancisco SanzOriol SibilaAna Rodrigo-troyanoJordi Solé-violánAne UrangaJob Fm Van BovenEster Vendrell TorraJordi Almirall PujolCharles FeldmanHo Kee YumArnauld Attannon FiogbeFerdaous YanguiSemra BilacerogluLevent DalarUfuk YilmazArtemii BogomolovNaheed ElahiDevesh J DhasmanaAndrew FeneleyRhiannon IonsJulie SkeemerGerrit WoltmannCarole HancockAdam T HillBanu RudranSilvia Ruiz-buitragoMarion CampbellPaul WhitakerAlexander YouzguinAnika SinganayagamKaren S AllenVeronica BritoJessica DietzClaire E DysartSusan M KellieRicardo A Franco-sadudGarnet MeierMina GagaThomas L HollandStephen P BerginFayez KheirMark LandmeierManuel LoisGirish B NairHemali PatelKatherine ReyesWilliam Rodriguez-cintronShigeki SaitoNilam J SoniJulio NodaCecilia I HinojosaStephanie M LevineLuis F AngelAntonio AnzuetoK Scott WhitlowJohn HipskindKunal SukhijaVicken TottenRichard G WunderinkRay D ShahKondwelani John MateyoLorena NoriegaEzequiel AlvaradoMohamed AmanLucía Labra

subject

Maleantibiotic resistancePrevalenceMRSAmedicine.disease_causepneumonia; antibiotic resistance; staphylococcus aureus; MRSAGlobal HealthCohort Studies0302 clinical medicineCommunity-acquired pneumoniaRisk FactorsRetrospective StudiePrevalenceCommunity-Acquired Infection030212 general & internal medicineeducation.field_of_studyCross InfectionRespiratory tract infectionsMethicillin-Resistant Staphylococcus aureuStaphylococcal InfectionsHospitalsCommunity-Acquired InfectionsInfectious DiseasesInfectious diseasesFemaleHumanMethicillin-Resistant Staphylococcus aureusstaphylococcus aureusmedicine.medical_specialtyPopulationAdmissionstaphylococcus aureuSettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesHospitalInternal medicinemedicineHumanspneumoniaRisk factoreducationIntensive care medicineStaphylococcal InfectionRetrospective StudiesAgedbusiness.industryRisk FactorOdds ratioPneumoniamedicine.diseaseMethicillin-resistant Staphylococcus aureusPneumonia030228 respiratory systemMethicillin ResistanceCohort Studiebusiness

description

BACKGROUND: Antibiotic resistance is a major global health problem and pathogens such as meticillin-resistant Staphylococcus aureus (MRSA) have become of particular concern in the management of lower respiratory tract infections. However, few data are available on the worldwide prevalence and risk factors for MRSA pneumonia. We aimed to determine the point prevalence of MRSA pneumonia and identify specific MRSA risk factors in community-dwelling patients hospitalised with pneumonia.METHODS: We did an international, multicentre study of community-dwelling, adult patients admitted to hospital with pneumonia who had microbiological tests taken within 24 h of presentation. We recruited investigators from 222 hospitals in 54 countries to gather point-prevalence data for all patients admitted with these characteristics during 4 days randomly selected during the months of March, April, May, and June in 2015. We assessed prevalence of MRSA pneumonia and associated risk factors through logistic regression analysis.FINDINGS: 3702 patients hospitalised with pneumonia were enrolled, with 3193 patients receiving microbiological tests within 24 h of admission, forming the patient population. 1173 (37%) had at least one pathogen isolated (culture-positive population). The overall prevalence of confirmed MRSA pneumonia was 3·0% (n=95), with differing prevalence between continents and countries. Three risk factors were independently associated with MRSA pneumonia: previous MRSA infection or colonisation (odds ratio 6·21, 95% CI 3·25-11·85), recurrent skin infections (2·87, 1·10-7·45), and severe pneumonia disease (2·39, 1·55-3·68).INTERPRETATION: This multicountry study shows low prevalence of MRSA pneumonia and specific MRSA risk factors among community-dwelling patients hospitalised with pneumonia.FUNDING: None.

yearjournalcountryeditionlanguage
2016-12-01
10.1016/s1473-3099(16)30267-5https://www.sciencedirect.com/science/article/pii/S1473309916302675?via=ihub