6533b856fe1ef96bd12b281f
RESEARCH PRODUCT
Deficit of interleukin 7 in septic patients.
Constantino Tormo-calandínJuan Carlos Andreu-ballesterCarlos Garcia-ballesterosAna Peiró-gómezCarmen CuéllarCarlos Peñarroja-oteroJaime Pérez-grieraJosé MayansFerran BallesterVictoria Amigosubject
Malemedicine.medical_specialtyT cellT-LymphocytesImmunologyGastroenterologySepsisInternal medicineSepsismedicineImmunology and AllergyHumansIn patientLymphocyte CountSevere sepsisAgedPharmacologyAged 80 and overSeptic shockbusiness.industryInterleukin-7Healthy subjectsInterleukinReceptors Antigen T-Cell gamma-deltaMiddle Agedmedicine.diseasemedicine.anatomical_structureSpainCase-Control StudiesImmunologyDisease ProgressionFemalebusinessdescription
We recently demonstrated an overall decrease of all αβ and specially γδ T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of γδ T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death still has not been investigated. Sera from 78 patients who met criteria for sepsis were analyzed vs control group. Septic patients showed the lowest levels of IL-7. Patients with severe sepsis reached levels of IL-7 higher than those observed in the groups of uncomplicated sepsis and septic shock. The frequency of γδ T cells at admission was lower in septic patients vs control group. At the time of admission, the frequency of γδ T cells in septic patients who subsequently died was lower than the observed in the group of patients that instead survived.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-05-09 | International immunopharmacology |