6533b856fe1ef96bd12b2f95

RESEARCH PRODUCT

Induced pluripotent stem cells in liver disease

Laia TolosaM. Teresa DonatoMaría Pelechá

subject

Liver diseasemedicine.anatomical_structureSomatic cellLiver cellCellCancer researchmedicineHepatic stellate cellStem cellBiologymedicine.diseaseInduced pluripotent stem cellRegenerative medicine

description

Abstract The development of suitable and reproducible liver cell models is fundamental for regenerative medicine, drug screening, and disease modeling. Human primary hepatocytes are the gold standard not only for hepatic cell therapy but also for preclinical toxicological screening or the study of liver disease; however, their limited availability, variability, and phenotypic instability hamper their use. Recent advances in stem cell technology have allowed the generation of induced pluripotent stem cells (iPSCs) from different somatic cell types and their differentiation into hepatocyte-like cells (HLCs), which can provide unlimited cell source for their use in hepatology studies. We review in detail the advances in the protocols for generating iPSCs and differentiate them into HLCs and the application of these tools in different fields such as liver cell transplantation, drug-induced liver injury, or to model liver disease.

yearjournalcountryeditionlanguage
2021-01-01
https://doi.org/10.1016/b978-0-12-822229-4.00011-5