6533b856fe1ef96bd12b302b

RESEARCH PRODUCT

Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study

Amalia Diaz-lacavaNadine PetrovskyThomas F. WienkerNorbert ThueraufArian MobascherJuergen BrinkmeyerJürgen GallinatGerhard GründerLena RademacherHolger ThieleMichael WagnerFalk KieferChristina DinterJohannes KornhuberTomislav MajićChristoph Von Der GoltzNorbert DahmenGeorg WintererJochen MutschlerJochen MutschlerElvira Abbruzzese

subject

AdultCandidate genemedia_common.quotation_subjectPopulationEuropean Continental Ancestry Groupgenetics [Catechol O-Methyltransferase]Single-nucleotide polymorphism610 Medicine & healthCatechol O-MethyltransferasePolymorphism Single NucleotideWhite PeopleGermanymental disordersSNPMedicineHumanseducationmedia_commonGeneticseducation.field_of_studyCatechol-O-methyl transferasebusiness.industryAddictionSmokingPublic Health Environmental and Occupational Healthgenetics [Smoking]Tobacco Use Disorder2739 Public Health Environmental and Occupational HealthMiddle Agedmedicine.diseaseCase-Control Studies10054 Clinic for Psychiatry Psychotherapy and Psychosomaticsddc:640genetics [Tobacco Use Disorder]businessAddictive behaviorrs4680

description

Background The catechol-O-methyltransferase (COMT) modulates dopaminergic neurotransmission in the prefrontal cortex as well as in the mesolimbic reward system. Since the reward system mediates addictive behavior, the COMT gene is a strong candidate gene regarding the pathophysiology of tobacco dependence and smoking behavior. Because of rather conflicting results in previous studies, the purpose of the present study was to test for association between a functional genetic variant in the COMT gene (single nucleotide polymorphism [SNP] rs4680) and tobacco smoking behavior. Methods In a population-based case-control multicenter study designed for tobacco addiction research, a total of 551 current smokers of European ancestry and 548 age-matched healthy volunteers (never-smokers) were genotyped for SNP rs4680 and extensively characterized concerning their smoking behavior. Results We found no association between smoking status and SNP rs4680 genotype nor did we find a significant association to the degree of tobacco dependence. Conclusions Although prefrontal cortical and ventral striatal activity are highly relevant for addictive behavior, and under partial control of COMT rs4680 genotype, no association between COMT and smoking behavior was observed. Other genetic variants may account for the high heritability of behavioral smoking phenotypes.

yearjournalcountryeditionlanguage
2013-01-01
10.5167/uzh-91365https://doi.org/10.5167/uzh-91365