6533b856fe1ef96bd12b32a1
RESEARCH PRODUCT
Inhibition of T cell activityin vivo: a test model for quantitative evaluation
U. BotzenhardtE.-m. Lemmelsubject
C57BL/6T-LymphocytesT cellImmunologyGraft vs Host ReactionMice Inbred StrainsSpleenThymus GlandBiologyPharmacologyModels BiologicalGraft vs Host ReactionMiceIn vivoMethodsmedicineAnimalsImmunology and AllergyBioassayReactivity (chemistry)biology.organism_classificationSkin transplantationmedicine.anatomical_structureLiverImmunologySpleendescription
A test model is presented which, in comparison with the conventional models of skin transplantation or graft-versus-host (GvH) reaction in mice, permits a more sensitive quantitative evaluation of T cell inhibition in vivo. Prospective donors (type AA) are immunized with prospective recipient material (type AB); the resulting T cell reaction of A versus B is inhibited by consecutive treatment. Extent of inhibition can be evaluated after transfer of the pretreated AA material onto AB recipients by calculation of remaining GvH reactivity, if compared to adequate control tranfers. In this model the target animal for T cell reactivity (the AB recipient) remains untouched from immunosuppressive regimen.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1976-05-01 | European Journal of Immunology |