The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease

6533b857fe1ef96bd12b450b

RESEARCH PRODUCT

The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease

Gaspare Parrinello Carlo Maida Giulio Marchesini Cesare Gagliardo Antonino Tuttolomondo Giuseppe La Tona Calogero Cammà Giuseppe Brancatelli S. Petta G. Merlino Daniele Torres R. Zafonte Antonio Craxì Daniela Cabibi L. Galvano Massimo Midiri Vito Di Marco Anna Licata Antonio Pinto F. Magliozzo

subject

Liver Cirrhosis Male Pathology Biopsy Severity of Illness Index Gastroenterology 0302 clinical medicine Risk Factors Non-alcoholic Fatty Liver Disease Fibrosis Nonalcoholic fatty liver disease Ultrasonography 4500 Brain Diseases Settore MED/12 - Gastroenterologia medicine.diagnostic_test Medicine (all)Brain Disease General Medicine Middle Aged Magnetic Resonance Imaging White Matter Frontal Lobe medicine.anatomical_structure Liver Female 030211 gastroenterology & hepatology NAFLD liver biopsy fibrosis white matter lesions Research Article Human medicine.medical_specialty Liver Cirrhosi Observational Study Settore MED/08 - Anatomia Patologica Diagnosis Differential White matter 03 medical and health sciences Internal medicine Biopsy Severity of illness medicine Humans business.industry Risk Factor nutritional and metabolic diseases medicine.disease digestive system diseases Hyperintensity Differential diagnosis Steatosis Settore MED/36 - Diagnostica Per Immagini E Radioterapia business 030217 neurology & neurosurgery

description

Abstract We tested whether nonalcoholic fatty liver disease (NAFLD) and/or its histological severity are associated with vascular white matter lesions (WML) in patients with biopsy-proven NAFLD and in non-NAFLD controls. Data were recorded in 79 consecutive biopsy-proven NAFLD, and in 82 controls with normal ALT and no history of chronic liver diseases, without ultrasonographic evidence of steatosis and liver stiffness value 45 years (OR 3.09, 95% CI: 1.06–9.06, P = 0.03; and OR 11.1, 95% CI: 1.14–108.7, P = 0.03), and F2–F4 fibrosis (OR 3.36, 95% CI: 1.29–8.73, P = 0.01; and OR 5.34, 95% CI: 1.40–20.3, P = 0.01) were independently associated with WML (mostly of mild grade) by multivariate analysis. Among NAFLD, the prevalence of WML progressively increased from patients without (1/18; 5.5%), or with 1 (1/17, 5.8%), to those with 2 (9/30; 30%) and further to those with 3 (12/14; 85.7%) risk factors. The presence of WML is not associated with NAFLD, but with metabolic diseases in general, and fibrosis severity of NAFLD. Clinical implications of this issue need to be assessed by longitudinal studies.

year	journal	country	edition	language
2016-04-22	Medicine

https://doi.org/10.1097/md.0000000000003446