6533b857fe1ef96bd12b454b

RESEARCH PRODUCT

Analysis of drugs including illicit and new psychoactive substances in oral fluids by gas chromatography-drift tube ion mobility spectrometry

Sergio ArmentaAriadna DeniaFrancesc A. Esteve-turrillas

subject

Detection limitAnalyteChloroformChromatographyIon-mobility spectrometryMethyloneGas Chromatography-Mass SpectrometryAnalytical ChemistryAmphetaminechemistry.chemical_compoundCertified reference materialsCocainePharmaceutical PreparationschemistryLiquid–liquid extractionIon Mobility SpectrometrymedicineGas chromatographymedicine.drug

description

Abstract In this study, a gas chromatograph (GC) has been coupled to a drift tube ion mobility spectrometer (IMS) in order to develop an analytical procedure for the determination of psychoactive substances in oral fluids. Working parameters, including the GC-IMS interface ones, were adjusted in order to obtain sensitive and robust signals. A volume of 500 μL of oral fluid was extracted with 250 μL chloroform and, after centrifugation, were injected into the GC-IMS system. Amphetamine, methylone, α-PVP, ketamine, lidocaine, MPHP, cocaine, THJ-2201, and 5F-ADB were employed as model compounds, providing limits of detection from 6 to 15 μg L−1 and recoveries from 70 to 115% for field oral fluids spiked with target analytes at 250, 500, and 600 μg L−1. Moreover, two oral fluid certified reference materials were analysed by the proposed GC-IMS based methodology with obtained relative percentage errors lower than 8.4%, being the proposed GC-IMS procedure a reliable, selective, and sensitive technique for the determination of psychoactive substances in oral fluids.

yearjournalcountryeditionlanguage
2021-07-21Talanta
https://doi.org/10.1016/j.talanta.2021.122966