Intra-arterial idarubicin_lipiodol without embolization can provide prolonged complete response in hepatocellular carcinoma: A case report.

6533b857fe1ef96bd12b4736

RESEARCH PRODUCT

Intra-arterial idarubicin_lipiodol without embolization can provide prolonged complete response in hepatocellular carcinoma: A case report.

Sophie Gehin Mathieu Boulin Pauline Pistre Guiu Boris

subject

Male Hepatocellular carcinoma [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging medicine.medical_treatment Gastroenterology Ethiodized Oil 0302 clinical medicine MESH: Infusions Intra-Arterial MESH: Liver Neoplasms Pharmacology (medical)Embolization MESH: Carcinoma Hepatocellular Complete response MESH: Treatment Outcome MESH: Aged Standard treatment Liver Neoplasms [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 3. Good health Treatment Outcome Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Lipiodol 030211 gastroenterology & hepatology medicine.drug medicine.medical_specialty Intra-arterial therapy Carcinoma Hepatocellular Antineoplastic Agents [SDV.CAN]Life Sciences [q-bio]/Cancer 03 medical and health sciences MESH: Ethiodized Oil Internal medicine medicine Humans Infusions Intra-Arterial Idarubicin Contraindication Aged MESH: Humans business.industry MESH: Idarubicin medicine.disease digestive system diseases MESH: Male Regimen MESH: Antineoplastic Agents business Idarubicin

description

International audience; Hepatocellular carcinoma is the fourth leading cause of cancer death. For unresectable intermediate-stage hepatocellular carcinoma, the standard treatment is transarterial chemoembolization. To date, the overall survival at three years remains low, and there is currently no consensus about the best anticancer agent and optimal treatment regimen. We report the case of a hepatocellular carcinoma patient with a vascular contraindication to embolization who achieved a complete response after four intra-arterial infusions of idarubicin emulsified with lipiodol. The patient maintained his response over a three-year period without any hepatocellular carcinoma treatment, demonstrating the major role of the anticancer agent in the efficacy of transarterial therapies for intermediate-stage hepatocellular carcinoma.

year	journal	country	edition	language
2020-03-01

10.1177/1078155219861422 https://hal.umontpellier.fr/hal-03360231

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