6533b857fe1ef96bd12b4e7c

RESEARCH PRODUCT

Agouti-Related Proteins (AGRPs) and Agouti-Signaling Peptide (ASIP) in Fish and Chicken

Helgi B. SchiöthJanis KlovinsJanis Klovins

subject

Takifugu rubripesMolecular Sequence DataTetraodon nigroviridisGeneral Biochemistry Genetics and Molecular BiologySpecies SpecificityHistory and Philosophy of Sciencebiology.animalDatabases GeneticAnimalsAgouti-Related ProteinAmino Acid SequenceTetraodonGeneZebrafishPeptide sequencePhylogenyGeneticsbiologyFuguGeneral Neurosciencedigestive oral and skin physiologyFishesProteinsVertebratebiology.organism_classificationAgouti Signaling ProteinIntercellular Signaling Peptides and ProteinsChickens

description

We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C-terminal part of agouti-related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two from Fugu (Takifugu rubripes), and three from Tetraodon (Tetraodon nigroviridis). We have thus shown for the first time that both AGRP and ASIP genes exist in many species in "lower vertebrates" and were most probably present in early stages of vertebrate evolution.

yearjournalcountryeditionlanguage
2005-04-01Annals of the New York Academy of Sciences
https://doi.org/10.1196/annals.1327.063