Oxidative stress in bisphosphonate-related osteonecrosis of the jaws

6533b857fe1ef96bd12b508e

RESEARCH PRODUCT

Oxidative stress in bisphosphonate-related osteonecrosis of the jaws

Carmen Gavaldá-esteve M. Carmen Tormos Carlos Camps Leticia Bagan Guillermo-t. Sáez Jose V. Bagan Manuel Leopoldo-rodado Javier Calvo

subject

Male Cancer Research Saliva Oral Hygiene Index medicine.medical_treatment medicine.disease_cause Gastroenterology chemistry.chemical_compound fluids and secretions Adrenal Cortex Hormones Malondialdehyde Diphosphonates Glutathione Disulfide Dental Plaque Index Middle Aged Malondialdehyde Glutathione 8-Hydroxy-2'-Deoxyguanosine Periodontics Administration Intravenous Bisphosphonate-Associated Osteonecrosis of the Jaw Female Oral Surgery Multiple Myeloma medicine.medical_specialty Antineoplastic Agents Breast Neoplasms Pathology and Forensic Medicine Sex Factors Internal medicine medicine Humans Saliva Aged Bisphosphonate-associated osteonecrosis of the jaw DMF Index business.industry Deoxyguanosine Glutathione Bisphosphonate medicine.disease Surgery Oxidative Stress Otorhinolaryngology chemistry Case-Control Studies Glutathione disulfide Osteonecrosis of the jaw business Biomarkers Oxidative stress

description

Objectives To analyze whether oxidative stress (OS) changes are present in patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ) versus controls. Materials and Methods Oxidative stress was analyzed in serum and unstimulated saliva of three groups: Group 1 consisted of 24 patients who had been treated with intravenous bisphosphonates (ivBPs) and developed BRONJ, group 2 consisted of 20 patients who had received ivBPs and did not develop BRONJ, and group 3 comprised 17 control subjects. Reduced glutathione (GSH), malondialdehyde (MDA), oxidized glutathione (GSSG), and 8–oxo-7,8-dihydro-2-deoxyguanosine (8-oxo-dG) levels, as well as the GSSG/GSH ratio, were measured. Results Mean serum and saliva levels of MDA, GSSG, and 8-oxo-dG and the GSSG/GSH ratio were significantly higher in patients with BRONJ than in controls. We found no significant difference in OS according to BRONJ stage, sex, or location in the jaws. Logistic regression analysis revealed that the GSSG/GSH ratio was a significant factor predicting the development of BRONJ (P = 0.01). Conclusions Oxidative stress was detected in patients with BRONJ, and the GSSG/GSH ratio was the most significant OS variable found; it was a significant factor predicting the development of BRONJ.

year	journal	country	edition	language
2013-12-03	Journal of Oral Pathology & Medicine

https://doi.org/10.1111/jop.12151