6533b858fe1ef96bd12b5aca

RESEARCH PRODUCT

Nitroglycerin Hits the Nerve

Ulrich HinkMohamed-saiel S. AlhamdaniThomas Münzel

subject

business.industryMitochondrial Aldehyde DehydrogenaseChronic anginaCalcitonin gene-related peptidePharmacologymedicine.diseaseOrganic nitratesAnesthesiaHeart failuremedicineCardiology and Cardiovascular MedicinebusinessNitroglycerinmedicine.drug

description

Organic nitrates are still widely used for the treatment of acute and chronic angina and congestive heart failure. When given acutely, their effectiveness is indisputable; in contrast, their long-term efficacy is limited because of serious side effects such as the development of tolerance and

https://doi.org/10.1016/j.jacc.2008.06.014