6533b858fe1ef96bd12b5b38
RESEARCH PRODUCT
Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring.
Pavel VodickaMikko KoskinenMichael ArandFranz OeschKari Hemminkisubject
Health Toxicology and MutagenesisMetabolitePopulation10050 Institute of Pharmacology and Toxicology610 Medicine & healthBiologyIn Vitro Techniquesmedicine.disease_causeRisk AssessmentStyrenechemistry.chemical_compoundDNA Adducts1311 GeneticsOccupational ExposureBiomonitoring2307 Health Toxicology and MutagenesisGeneticsmedicineAnimalsHumanseducationStyreneGeneticseducation.field_of_studyPrimary (chemistry)Binding SitesDNAchemistryBiochemistry570 Life sciences; biologyEpoxy CompoundsXenobioticGenotoxicityDNABiomarkersEnvironmental MonitoringMutagensdescription
Styrene is an important industrial chemical that has shown genotoxicity in many toxicology assays. This is believed to be related to the DNA-binding properties of styrene-7,8-oxide (SO), a major metabolite of styrene. In this review, we have summarized knowledge on various aspects of styrene genotoxicity, especially in order to understand the formation and removal of primary DNA lesions, and the usefulness of biomarkers for risk assessment. Biological significances of specific DNA adducts and their role in the cascade of genotoxic events are discussed. Links between markers of external and internal exposure are evaluated, as well as metabolic aspects leading to the formation of DNA adducts and influencing biomarkers of biological effect. Finally, we suggest a design of a population study, which may contribute to our understanding genotoxic events in the exposure either to single xenobiotic or complex mixture.
year | journal | country | edition | language |
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2002-07-01 | Mutation research |