6533b858fe1ef96bd12b61ab

RESEARCH PRODUCT

Indole alkaloids from the coprophilous fungus Aphanoascus fulvescens

Zhen LiuKun ZouXiaoqin YuZhiyong GuoWenhan LinPeter ProkschWerner E. G. M�ller

subject

PharmacologyIndole testbiology010405 organic chemistryChemistryStereochemistryMouse LymphomaGeneral MedicineFungusAphanoascus fulvescensbiology.organism_classification01 natural sciences0104 chemical sciences010404 medicinal & biomolecular chemistryGoosebiology.animalDrug DiscoveryIc50 valuesCytotoxicityTwo-dimensional nuclear magnetic resonance spectroscopy

description

Abstract The Ascomycete fungus Aphanoascus fulvescens isolated from goose dung was investigated for its secondary metabolites, yielding five new indole alkaloids okaramines V–Z (1–5) and eleven known derivatives (6–16). Their structures were determined by 1D, 2D NMR spectra and HRMS data. Compounds 6, 8, 11 and 12 showed significant to moderate cytotoxicity against the mouse lymphoma cell line L5178Y with IC50 values ranging from 4.0 to 14.7 μM. Preliminary structure-activity relationships are discussed.

yearjournalcountryeditionlanguage
2019-07-01Fitoterapia
https://doi.org/10.1016/j.fitote.2019.05.007