6533b858fe1ef96bd12b61ac
RESEARCH PRODUCT
Histiocytosis with mixed cell populations
José M. MartínGerardo BetetaCarlos MonteagudoAlejandro Martin-gorgojoEsperanza Jordásubject
Pathologymedicine.medical_specialtyHistologyLangerinbiologyBirbeck granulesJuvenile xanthogranulomaDermatologyHistogenesismedicine.diseasePathology and Forensic Medicine030207 dermatology & venereal diseases03 medical and health sciencesHistiocytosis0302 clinical medicineLangerhans cell histiocytosis030220 oncology & carcinogenesismedicinebiology.proteinIndeterminate Cell HistiocytosisImmunostainingdescription
Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-04-04 | Journal of Cutaneous Pathology |