Squamoid eccrine ductal carcinoma

Remisión espontánea de verrugas recalcitrantes en niñas tras vacunación frente al virus del papiloma humano

Parvovirus B19-Associated Microvesicular Eruption

We report on a 3-year-old girl with a microvesicular generalized rash in whom primary infection by parvovirus B19 was demonstrated by seroconversion. To our knowledge, this is the first instance of an eruption arising from parvovirus B19 with this peculiar clinical pattern.

Vascularización en dermatoscopia

Resumen La dermatoscopia permite observar, en las condiciones adecuadas, la vascularizacion presente en las lesiones cutaneas de muy diversa indole. La visualizacion e identificacion de vasos de morfologia caracteristica puede ser la clave en el diagnostico de determinadas lesiones, especialmente en el caso de aquellas hipopigmentadas, en las que no es posible identificar las estructuras pigmentadas clasicas. Asi pues, algunas de las asociaciones mas caracteristicas son la presencia de vasos «en corona» en la hiperplasia sebacea, las «telangiectasias arboriformes» en el carcinoma basocelular, los vasos «en coma» en los nevos intradermicos y compuestos, los vasos «en cabeza de alfiler» en lo…

Azithromycin for the Treatment of Ciclosporin-Induced Gingival Hyperplasia

Regresión completa de nevos melanocíticos: correlación clínica, dermatoscópica e histológica de una serie de 13 casos

Resumen Antecedentes y objetivos La regresion completa de neoplasias melanociticas, confirmada mediante estudio histologico, se ha descrito de forma excepcional en la literatura. En esos casos es muy complicado discernir si la lesion previa era maligna o benigna, y en ocasiones tan solo la presencia o ausencia de metastasis en el seguimiento posterior del paciente permite establecer dicha distincion. Metodos Se realizo un analisis descriptivo que incluyo los nevos melanociticos extirpados en nuestro Servicio de Dermatologia en un periodo de tres anos, en los que el estudio histologico demostro una regresion completa de los mismos. Se analizaron exclusivamente aquellas lesiones de las cuales…

Utilidad de la azitromicina en la hiperplasia gingival inducida por ciclosporina

Familial seborrhoeic keratosis associated with multiple 'pure reticulated acanthomas' and infundibulocystic basal cell carcinomas.

Background A variety of genodermatoses with multiple cutaneous tumors with germline genetic alterations such as Gorlin syndrome with PTCH1 gene mutations have been described. Other cutaneous syndromes have been associated with somatic gene mutations, such as FGFR3 in familial seborrhoeic keratosis. Objective We describe the clinical, dermoscopic, and histopathological features of multiple cutaneous lesions, mostly infundibulocystic basal cell carcinomas and pure reticulated acanthomas, present in a family affected by familial seborrhoeic keratosis. In addition, we tested for possible germline alterations in the FGFR3 and PTCH1 genes. Methods Ten members of one family were clinically examine…

Leukocytoclastic vasculitis associated with sulfuric acid inhalation

Progressively fading asymptomatic brownish macules

Complete Regression of Melanocytic Nevi: Correlation Between Clinical, Dermoscopic, and Histopathologic Findings in 13 Patients

Background: The complete regression of melanocytic tumors, confirmed by histology, has rarely been reported in the literature. It is very difficult to determine the malignant or benign nature of a regressed tumor, and on occasions, the only indication of malignancy is the subsequent development of metastasis. Material and methods: We performed a descriptive study of melanocytic nevi that had undergone complete, histologically confirmed regression prior to excision in the dermatology department of our hospital over a period of 3 years. We included only lesions in which dermoscopy performed prior to regression showed features that suggested benignity. We assessed various clinical, dermoscopic…

Pruriginous Lesions in a Young Girl: Challenge.

Novel Immunologic Approaches to Melanoma Treatment

Approaches to treating melanoma have changed radically since the introduction of immunotherapy, and survival figures are now higher than possible with earlier therapies. The immunomodulators currently available mainly block CTLA-4 (cytotoxicT lymphocyte-associated molecule-4) and PD-1 (programed cell death protein 1) translocated to the cell surface, where they inhibit the antitumor immune response. Treatments blocking these molecules are being more widely used. Research now seeks new molecular targets, the best combinations of available drugs, and biomarkers that can identify ideal candidates for each one.

Atypical Phacomatosis Pigmentokeratotica as the Expression of a Mosaic RASopathy With the BRAF-Glu586Lys Mutation

Novedades en inmunología del melanoma

Resumen Desde la introduccion de la inmunoterapia el tratamiento del melanoma ha sufrido una revolucion, consiguiendose cifras de supervivencia superiores a las que se alcanzaban con los tratamientos previos. Los farmacos inmunomoduladores disponibles actualmente van dirigidos principalmente frente a las moleculas de superficie CTLA-4 y PD-1, que ejercen un efecto inhibidor sobre la respuesta inmune antitumoral. Se trata de un tratamiento en pleno proceso de expansion, y la investigacion se dirige hacia el descubrimiento de nuevas moleculas, las combinaciones de los farmacos disponibles o la identificacion de biomarcadores que permitan seleccionar a los pacientes idoneos para cada terapia.

La diferenciación perineural en los tumores cutáneos

Spontaneous regression of multiple melanocytic nevi after melanoma: report of 3 cases.

Complete spontaneous regression of multiple melanocytic nevi after melanoma is an extremely rare phenomenon. We report 3 cases of patients with a history of melanoma that showed regression of almost all melanocytic nevi over time. One of the patients had 2 simultaneous primary cutaneous melanomas without metastasis. In the other 2 patients, regression of the melanocytic nevi was seen after the development of metastasis in lymph nodes. These patients had spontaneously developed an efficient immune response against melanocytes, and they would represent paradigmatic examples of the spontaneous immune responses in melanoma patients. Better understanding of the mechanisms involved in the complet…

Blueberry Muffin Baby Associated with Bone Demineralization Due to Congenital Transient Neonatal Hyperparathyroidism

Papular pruritic eruption with human immunodeficiency virus infection.

Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient

CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: correlation with clinicopathological prognostic factors.

A role for CXCR3, the receptor for chemokines Mig, IP-10 and interferon-inducible T cell alpha-chemoattractant, in tumour cell migration during melanoma progression has been proposed.To analyse CXCR3 expression in primary cutaneous malignant melanomas and its comparison with clinicopathological and prognostic factors.A retrospective immunohistochemical study was carried out on formalin-fixed paraffin-wax-embedded sections from 82 patients with primary invasive cutaneous melanomas, with a monoclonal antibody to CXCR3 (clone 49801.111; RD Systems). Immunoreactivity was semiquantitatively evaluated: labelling intensity (0, absent; 1, weak; 2, moderate; 3, strong) multiplied by the percentage o…

Progressive depigmentation of a melanocytic lesion: a dermoscopic challenge for melanoma diagnosis.

Spontaneous Remission of Recalcitrant Warts in Girls After Human Papillomavirus Vaccination

Florid fibroplasia in melanocytic lesions. A retrospective study.

Histiocytosis with mixed cell populations

Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.

Vascular Patterns in Dermoscopy

Under the right conditions, dermoscopy allows us to observe the vascular features of many different types of skin lesions. The visualization and identification of vessels with a characteristic morphology can be the key to diagnosis, especially in hypopigmented lesions in which the typical pigmented structures are not visible. Some of the more characteristic associations are the presence of crown vessels in sebaceous hyperplasia, arborizing telangiectasias in basal cell carcinoma, comma-shaped vessels in intra- dermal and compound nevi, dotted vessels in Spitz nevi and melanoma, and hairpin vessels in seborrheic keratoses. The recognition of distinctive vascular features can be of great help…

Actualización en el síndrome Birt-Hogg-Dubé

Resumen El sindrome de Birt-Hogg-Dube (SBHD) es una rara genodermatosis de herencia autosomica dominante caracterizada esencialmente por la presencia de fibrofoliculomas y/o tricodiscomas, quistes pulmonares, neumotorax espontaneos y canceres renales, siendo los tipos histologicos mas frecuentes las formas hibridas de oncocitoma y carcinoma cromofobo o formas puras de carcinoma cromofobo, oncocitico, de celulas claras o papilar. El gen implicado en este sindrome, FLCN, codifica la foliculina, que se expresa preferentemente a nivel cutaneo, renal y pulmonar. Este sindrome puede presentarse con una gran variabilidad clinica, y las lesiones cutaneas que son el signo de alarma para los dermatol…

Telomeric length heterogeneity influences spontaneous regression of malignant melanoma

Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers.

Aims:  To evaluate the clinicopathological and immunohistochemical characteristics of Merkel cell carcinoma (MCC) in an attempt to find new, potentially significant, prognostic markers. Methods and results:  Clinical data and follow-up, histopathological features (pattern, cell size, thickness, mitoses, vascular invasion, lymphocytic infiltration) and immunohistochemical detection [CK20, thyroid transcription factor (TTF-1), chromogranin A, synaptophysin, p53, Ki67, Fli-1, CD99, c-Kit] were evaluated in 20 cases of MCC. Fli-1 and CD99 were detected in 90% and 55% of cases, respectively. Tumour size > 30 mm, stage II, ‘absent’ lymphocytic infiltration, and the presence of > 50% of Ki67+ tumo…

Descriptive Dermoscopic Study of Depigmentation in Melanocytic Nevi Without a Visible Halo

Background and objectives: There are few cases described in the literature in which depigmentation of melanocytic nevi occurs without the appearance of halos. The aim of this study was to analyze the correlation between clinical and dermoscopic findings and to assess the usefulness of dermoscopy to identify possible markers of complete regression in melanocytic lesions. Materials and methods: A prospective, observational, descriptive study of 77 melanocytic lesions in 52 patients was undertaken over a 5-year period. Melanocytic lesions from patients who underwent periodic follow-up in the digital dermoscopy unit were analyzed if they had exhibited partial or total, permanent depigmentation …

Estudio descriptivo dermatoscópico de los nevos melanocíticos con despigmentación sin halo clínico

Resumen Introduccion la despigmentacion de nevos melanociticos sin halo perilesional se ha descrito de forma excepcional en la literatura. Material y metodos estudio observacional, descriptivo y prospectivo de 77 lesiones melanociticas correspondientes a 52 pacientes, llevado a cabo durante un periodo de 5 anos. Se han analizado las lesiones melanociticas de pacientes revisados periodicamente en la unidad de dermatoscopia digital que habian sufrido una despigmentacion permanente, ya fuera total o parcial, pero sin presentar clinicamente un halo blanquecino alrededor de los mismos. El objetivo fue estudiar la correlacion entre los hallazgos clinicos y dermatoscopicos a estudio, y establecer …

Erythrophagocytic tumour cells in melanoma and squamous cell carcinoma of the skin

Aims: Erythrophagocytosis is a characteristic feature of tumour cells in malignant histiocytosis, some leukaemias, lymphomas, and also reactive histiocytes in the haemophagocytic syndrome associated with a variety of infections and neoplasms. It has also been found exceptionally in metastatic malignant epithelial cells in bone marrow and lymph nodes. We present two cases, a cutaneous malignant melanoma and an acantholytic squamous cell carcinoma, in which erythrophagocytosis by tumour cells was demonstrable by both light and electron microscopy. Methods and results: The melanocytic and squamous nature of these cells was supported by the immunohistochemical detection of HMB45, S100, and NKI-…

Birt–Hogg–Dubé Syndrome: An Update

Birt-Hogg-Dube syndrome is a rare autosomal dominant genodermatosis that is characterized by the presence of fibrofolliculomas and/or trichodiscomas, pulmonary cysts, spontaneous pneumothorax, and renal tumors. The most common histological types found in renal tumors from patients with the syndrome are oncocytoma-chromophobe carcinoma hybrids and pure forms of chromophobe carcinoma, oncocytic carcinoma, and clear cell or papillary cell carcinoma. The syndrome is linked to mutations in the FLCN gene, which encodes folliculin and is preferentially expressed in the skin, kidney, and lung. The syndrome can exhibit a high degree of clinical variability, and the skin lesions that are a warning si…