6533b830fe1ef96bd1297009
RESEARCH PRODUCT
Spontaneous regression of multiple melanocytic nevi after melanoma: report of 3 cases.
Carlos MonteagudoIsabel PinazoAndrea AllendeJosé MartínJelena MarkovicEsperanza Jordásubject
AdultMaleLymphatic metastasismedicine.medical_specialtySkin NeoplasmsTime FactorsAdolescentmedicine.medical_treatmentBiopsyDermoscopyDermatologyPathology and Forensic MedicineMetastasisFatal OutcomeComplete regressionBiopsymedicineNevusHumansneoplasmsMelanomaNevus Pigmentedmedicine.diagnostic_testbusiness.industryMelanomaGeneral MedicineImmunotherapymedicine.diseaseDermatologyRegressionTreatment OutcomeNeoplasm Regression SpontaneousLymphatic MetastasisDisease ProgressionLymph Node ExcisionMelanocytesFemalebusinessdescription
Complete spontaneous regression of multiple melanocytic nevi after melanoma is an extremely rare phenomenon. We report 3 cases of patients with a history of melanoma that showed regression of almost all melanocytic nevi over time. One of the patients had 2 simultaneous primary cutaneous melanomas without metastasis. In the other 2 patients, regression of the melanocytic nevi was seen after the development of metastasis in lymph nodes. These patients had spontaneously developed an efficient immune response against melanocytes, and they would represent paradigmatic examples of the spontaneous immune responses in melanoma patients. Better understanding of the mechanisms involved in the complete regression of melanocytic lesions would lead to a better selection of melanoma patients for immunotherapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-25 | The American Journal of dermatopathology |