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RESEARCH PRODUCT
Novel Immunologic Approaches to Melanoma Treatment
Esperanza JordáJosé M. MartínI. Escandellsubject
Clinical OncologyHistologybusiness.industrymedicine.medical_treatmentMelanomaCellDermatologyImmunotherapymedicine.diseasePathology and Forensic Medicine03 medical and health sciences0302 clinical medicinemedicine.anatomical_structureImmune system030220 oncology & carcinogenesisImmunologyMolecular targetsCancer researchMedicine030212 general & internal medicineAvailable drugsbusinessdescription
Approaches to treating melanoma have changed radically since the introduction of immunotherapy, and survival figures are now higher than possible with earlier therapies. The immunomodulators currently available mainly block CTLA-4 (cytotoxicT lymphocyte-associated molecule-4) and PD-1 (programed cell death protein 1) translocated to the cell surface, where they inhibit the antitumor immune response. Treatments blocking these molecules are being more widely used. Research now seeks new molecular targets, the best combinations of available drugs, and biomarkers that can identify ideal candidates for each one.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-10-01 | Actas Dermo-Sifiliográficas (English Edition) |